The methods used to surgically implant telemetry units to measure cardiovascular function and body temperature in nonhuman primates can impact the quality of the study information obtained.

In a recent case study, Altasciences compared the quality of data capture of the standard intra-abdominal implant method versus a less invasive subcutaneous implant method.

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Nonclinical safety evaluation generally includes a characterization of toxic effects with respect to target organs, dose dependence, relationship to exposure and, when appropriate, potential reversibility. Nonclinical safety studies, although usually limited at the beginning of clinical development, should be adequate to characterize potential adverse effects that might occur under the conditions of the clinical trial to be supported.

With over 25 years of experience in conducting nonclinical studies, you can rely on Altasciences for your program, and learn what preclinical criteria are needed to support your first-in-human clinical trials.

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At Altasciences, our integrated, full-service solutions from lead candidate selection to clinical proof of concept are all customizable to your specific needs.

Watch as Ingrid Holmes, Vice President, Global Clinical Operations, discusses how we help sponsors bring better drugs to market, faster.

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Altasciences is always looking ahead. Our team of experts planned for potential shortages of nonhuman primate (NHP) supply, and took action to guarantee access. To ensure NHP supply and on-time study start dates, Altasciences entered into a four-year agreement to secure Cambodian primates.