Preclinical Research
Geometric Determinants of Full-Thickness Wound Healing in Adult Male Yucatan Miniature Swine
Development of a Model of Dermal Inflammation and Irritation (Urticaria) in Miniature Swine
Dermal Toxicology Application Area Changes as Compared to a Theoretical Total Surface Area of Hanford Miniature Swine Over 18 Weeks
Acute Dermal Irritation Response in White Sinclair and Hanford Miniature Swine
Test Your Knowledge of PCR Applications
PCR testing and analysis is a reliable way to screen many genetic markers and disease exposures including COVID-19 and other viruses. Its amplification process enables it to detect small segments or portions of genetic material in various samples to identify a specific source. PCR can also be used for a broad range of additional applications across forensics, drug development, and gene therapies.
Case Study―Safety Assessment of Intravitreal Implants in Dutch Belted Rabbits
ISSUE NO. 27 — The Complexities of Early-Phase Ophthalmic Drug Development
Ophthalmic medications have a particular set of challenges that can impact their speedy and successful path to market. From prototype formulation through preclinical testing, early-phase clinical and manufacturing and development, ophthalmic drug development presents with specific and unique complexities. It is best to entrust drug development to a partner with regulatory knowledge, technical expertise, and a thorough understanding of the market in this growing therapeutic area. From current reality to future trends, being at the forefront of ophthalmic drug development delivers tangible benefits to sponsors.
In Issue 27 of The Altascientist, we dive into all areas of ophthalmic drug development, including:
- Prototype development, formulation, and manufacturing
- Preparing for first-in-human studies
- Species and strain selection parameters
- Routes of administration
- Specialized ocular assessments and equipment
- bioanalysis
- Phase I clinical research
- Phase II to commercialization
Three case studies are also included!
Comparing Cytokine Data to In-Life Parameters on Nonhuman Primates in Nonclinical Toxicology Studies
The Impact of Social Factors on Drug Development
Drug development exists within the context of interrelated social factors that impact its norms and practices.
One Integrated Solution for Meeting Your Preclinical to Clinical Drug Development Needs