Miniature Swine Considerations for Your Next Nonclinical Program

Did you know that miniature swine is often a viable option for your nonclinical program?

This complimentary webinar discusses the scientific rationale for miniature swine model selection for your non-rodent, nonclinical programs. In addition, we present the different miniature swine strains which may affect your species selection process.

Speak with an expert to learn more about the possibility of utilizing miniature swine for your upcoming nonclinical drug development program.

Refer to these two guidance documents which can help with your species selection:

• Preclinical Safety Evaluation of Biotechnology-Derived Pharmaceuticals S6(R1)
• M3(R2) Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals

Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single study or multiple programs, to offer an integrated/synchronized approach to CRO and CDMO services.

We are pleased to share with you the four scientific posters that were presented by our nonclinical experts at the annual SOT meeting.

Detection of Plasma Cells and their Precursors in Bone Marrow and Peripheral Blood 
Plasma cells are antibody-producing B cells that play a major role in conferring immune protection, but can also contribute to the pathogenesis of autoimmune diseases like multiple sclerosis, and hematologic cancers like multiple myeloma. Read more.

Evaluating Cytokine Data in Non-human Primate Safety Assessment Studies 
Cytokines are cell-signaling small proteins classified as either pro-inflammatory or anti-inflammatory. With the increasing number of biologics and immune-modulating drugs being developed, the evaluation of cytokine levels as potential biomarkers in safety assessment studies has become more common. Read more.

Historical Control Reference Values of Cambodian Cynomolgus Macaque Blood Gases 
Measuring blood gases can be useful in identifying drug-related respiratory changes like blood changes in the diffusion of gases from the lungs into the bloodstream. For small molecule pharmaceuticals, ICH S7 identifies hemoglobin oxygen saturation (sO2) as a potential part of the core respiratory battery, while other blood gases (e.g., pO2 and pCO2) can be used for supplemental assessment. Read more.

Multiplexed Cytokine Comparison Across Two Species Dosed with the Same Drug
Questions often asked include which assay platform to use (Meso Scale Discovery or Luminex xMAP^®), and how relatable are the results between small animals (e.g.,rats) and large animals (e.g., non-human primates)… Our analysis revealed commonalities and differences in cytokine responses across species. Read more.

Book a consult with one of our experts to discuss how we can support your program.


You may also be interested in the following:

• E-book: Preclinical Assessment Planning Guide
• Webpages:
  • Preclinical Solutions
  • Bioanalytical Solutions
  • Early Phase Drug Development Solutions

Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single study or multiple programs, to offer an integrated/synchronized approach to CRO and CDMO services.

Three Strategically Located Preclinical Sites

Our three preclinical sites work in unison with our clinical, bioanalytical and manufacturing sites to offer an integrated drug development solution from lead candidate selection to clinical proof of concept. We offer a full range of in vivo non-GLP and GLP preclinical studies in both rodent and non-rodent species to thoroughly assess the safety of your molecules.

Our purpose-built:

• 550,000 sq.-ft.
• 260 custom-designed animal rooms, including North-American and European housing
• Capacity to house 3,320 NHPs, 965 canines, 920 swine, 27,320 rodents, 2,480 rabbits
• Barrier facilities for small animals
• Archive facility and services on site
• Laboratory services on site

Let’s chat!

You may also be interested in the following:

• Preclinical Services
• Bioanalytical Services
• Clinical Services
• Manufacturing and Analytical Services

Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single study or multiple programs, to offer an integrated/synchronized approach to CRO and CDMO services.

Seamless Bioanalytical Transition

Altasciences’ scientists move in unison with you, collaboratively, accurately, and efficiently, from preclinical to clinical, and beyond. Our team of over 260 bioanalytical scientific veterans is strategically located across North America, and has experience with a wide spectrum of biological matrices in both animal and humans.
 
Driven by your assay requirements, our program support includes LC-MS/MS, LBA OR HYBRID LBA/LC-MS/MS ASSAY platforms for:

Speak with a scientist

Have 5 minutes? You may also be interested in the following:

• Assay List — Over 685 Assays covering 650 Molecules
• The Altascientist — Validation of Immunogenicity Assays
• Webinar — Development of a Cell-Based Assay for Dual Purposes: to Support Drug Potency and Immunogenicity Characterization

Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single study or multiple programs, to offer an integrated/synchronized approach to CRO and CDMO services.

The Benefits of Altasciences’ Unique Approach to Project Management

When you partner with Altasciences, you are assigned a dedicated
cross-functional project manager to seamlessly guide you from one milestone to the next — keeping your studies on track, throughout the lifecycle of your project.

In this complimentary webinar, learn about the benefits of Altasciences’ unique program management offering, including case studies and client testimonials. 

Watch now

You may also be interested in the following:  

• Fact Sheet: Integrated Research Services
• Video: QUICK CHAT with Lauren Szczurowski — A Seamless Experience with Scientific Project Management
• Webpages:
  • Proactive Drug Development
  • Project Management Capabilities

Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single service or a synchronized approach to CRO and CDMO services from lead candidate selection to clinical proof of concept, and beyond.