Bioanalysis

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  • Development of an Assay for Atropine in Rabbit Plasma by LC/MS/MS and the Impact of Atropine Esterase

    Maximize Assay Sensitivity and Minimize Costs


    Strategies to Improve Assay Sensitivity to Quantify Therapeutic Oligonucleotides

    Are you looking for assays with enhanced sensitivity and minimal sample clean-up in small volumes?

    We can help.

    Our strategies enhance analytical sensitivity, reduce assay costs, and streamline workflows, optimizing the efficiency and cost-effectiveness of your research and development processes.

    Discover this in this real-world example

    ​​​​Strategies to improve assay sensitivity to quantify therapeutic oligonucleotides

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    Discover Our Truly Integrated Clinical and Bioanalytical Solution


    The True Meaning of Moving in Unison

    Join our VP of Global Clinical Operations, Ingrid Holmes, and our VP of Laboratory Sciences, Lynne Le Sauteur, as they share the secrets to the success of our integrated clinical and bioanalytical solution. You won't want to miss this!

    Watch the full interview or keep scrolling to jump to a specific section.

    Dr Lynne Le Sauteur and Ingrid Holmes

    1. Proprietary Scheduling System:
      In this video, discover our game-changing, proprietary scheduling system, which is essential for hitting key client deliverables and managing internal milestones across departments and services with precision.

      Explore more about our innovative scheduling system here.

    2. Advantages of Being a Mid-Sized CRO:
      Flexibility and customized service are at the core of our operations. Our mid-sized stature allows for seamless communication between departments while offering comprehensive services.

      Discover the benefits of partnering with a flexible, mid-sized CRO here.

    3. Successful Project Case Study:
      In this interview, we highlight a real-world example of a challenging project where seamless communication and coordination, and the proximity of our lab and clinic were pivotal to exceeding client expectations and delivering outstanding results.

      See how we tackle complex projects successfully here.
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    Antisense oligonucleotides—or ASOs—are short, synthetic, single-stranded oligonucleotides  extensively used for altering RNA expression to reduce, restore, or modify protein expression via several distinct mechanisms. With possible applications extending to both neurological and non-neurological conditions, there is great potential for valuable new therapeutics.

    Strategies to Improve Assay Sensitivity to Quantify Therapeutic Oligonucleotides

    FREE ON-DEMAND WEBINAR—Key Considerations for Nonclinical AAV Gene Therapy


     

    From Screening to PCR Analysis

    In this webinar on AAV gene therapy, we explore pre-existing immunity challenges, vector targets, biodistribution, and the role of PCR analysis in assessing therapy efficacy and safety.

    Also included are case studies that highlight the delicate balance between innovation and regulatory compliance.

    Watch now!

    ​​​​Webinar BioAnalysis Gene Therapy

     

    ​​​You may also be interested in the following:

    ​​​ ​​​​​​​​​​​​The Altascientist
        •   qPCR and ddPCR—Leading-Edge Analysis for Gene Therapy Programs
         •  Nonclinical Studies in Cell and Gene Therapy

    ​​​Webpages
         •  Bioanalytical Services
         •  Preclinical Services

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    The gene therapy landscape continues to accelerate in preclinical and clinical research, with programs constantly in development for targeted, personalized medicines. The goal is to safely incorporate genetic alterations to restore and repair the proteins of missing and/or faulty genes.

    Strategies for Safe and Timely Shipments


     

    Your Samples Are in Good Hands With Us!

    From regulatory precision to preserving sample integrity, shipments can be challenging. Let us navigate and mitigate these challenges for you with a team of logistical experts to:

          •   Streamline regulatory compliance through optimized documentation practices.
          •   Prioritize secure, temperature-controlled shipments with reliable couriers.
          •   Ensure your samples maintain their integrity with temperature monitoring, robust packaging, and contingency planning.
          •   Our tailored concierge-style sample shipping ensures your test materials reach the correct destination safely and on time.

    Sample Logistics

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    How Mitra® Vams® Microsampling Device Redefines Sample Collection


     

    From Concept to Application

    Delve into the fascinating evolution and revolutionary advancements of the Mitra Vams microsampling device and its applications within life sciences with Dr. James Rudge, Microsampling Technical Director at Neoteryx, and Jeff Plomley, Scientific Director at Altasciences.

    Listen now!

     

    Microsampling with the Mitra Vams device

     

    Speak with one of our bioanalytical experts today.

     

    Related resources that may interest you:

    Microsampling Podcast Series:
    Episode 1: When Small Steps Lead to Big Outcomes
    Episode 2: Coupling Hybridization LC-MS Workflows With Microsampling​​​​

    The Altascientist: Microsampling in Drug Development

    Webpage: Microsampling in Early Drug Development

     

    Monitoring both cytokines and complement factors in drug development has become increasingly important, as the movement toward personalized treatments for cancers and genetic diseases has spurred research and development into biologics, vaccines, and small molecules that can have unintended consequences due to their immunomodulatory effects. 

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