Preclinical Research
JAK1-siRNA Treatment for Inflammatory Skin Diseases: Real-World Nonclinical Insights
Findings shared here were originally presented in a poster session at ACT 2025
Navigating to the Clinic: Key Aspects of Translational Pharmacology, By Bruce Morimoto
Drug development is not for the faint of heart; a twist on the Hunger Games saying, “May the odds be (n)ever in your favor,” might adequately characterizes the challenge. As scientists, however, we manage these inherent risks by establishing best practices and learning from our collective successes and failures, as well as. In this field, experience truly matters.
First-in-Human-Enabling Toxicology Programs: Common Misconceptions by Grace M. Furman
Nomination of a clinical candidate and subsequent conduct of toxicology studies to support a first-in-human (FIH) clinical trial is an exciting milestone for sponsors! While many are highly experienced drug discovery professionals, some may have limited, or even no experience, in early clinical development, including the critical toxicology studies required to successfully support a FIH trial.
The Year in Review 2025
First-Timer Perspectives on Attending the AALAS National Meeting, by Brandon Ossont and Jennifer Lakritz

The 76th annual American Association for Laboratory Animal Science (AALAS) National Meeting is a cornerstone event for the laboratory animal science community, bringing together researchers, veterinarians, technicians, and industry partners to share knowledge, i