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Opioids are highly effective at relieving both acute and chronic pain. However, this benefit comes at a significant cost: they are also highly addictive.

The Altascientist—Scientific Journal on Recent LC-MS/MS Innovations (includes six case studies!)

In this issue of The Altascientist, we cover the innovative progress we have recently seen in mass spectrometry, and how the advancements of science and technology can help you achieve critical milestones in your early phase drug development study or program.

In this issue you will explore:

  • The case for stable isotope labelled internal standards for LC-MS quantitation
  • Recent innovations in mass spectrometry
  • Six case studies

You may also be interested in the following:

WRIB 2022 Poster Presentation: Development of Surrogate CSF for Quantitative Analysis of ASOs by Hybridization LC-MS/MS

Webinars:

Podcast: Microsampling: When Small Steps Lead to Big Outcomes

Mastering the Art of Formulation

Your Formulations, Brewed to Perfection.

Pharmaceutical formulation is one of the most critical steps in early phase drug development. The successful formulation of your active pharmaceutical ingredient (API) will ensure a smooth transition to preclinical testing and clinical trials, and eventually to market.

Our experts have vast experience formulating both simple and complex formulations, using techniques such as nanomilling to successfully formulate even the most challenging, insoluble, or highly potent APIs―ensuring you have your preclinical and clinical study material on time.

Here's a glimpse of our scientists working their magic!

Do you have an API that needs to be formulated? Contact us to get started.

Related Resources:

Clinical Research Solution for Ophthalmic Products

Altasciences has extensive experience conducting early phase clinical trials for ophthalmic products targeting numerous eye diseases and disorders, such as open angle glaucoma, ocular hypertension, and dry eye.   

Our clinical solution includes:

  • In-house ophthalmologist with over 20 years of experience
  • Three North American inpatient units from coast to coast with over 500 beds — fully equipped inpatient and outpatient capabilities
  • Robust network of ophthalmology sites in close proximity to our clinics to conduct studies on both the front and back of the eyes
  • Database of over 400K participants for healthy normal and patient recruitment


Book a consult with one of our experts to learn more about our solution and how we can support your program. 

You may also be interested in the following:

 

Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single study or multiple programs, to offer an integrated/synchronized approach to CRO and CDMO services from lead candidate selection to clinical proof of concept, and beyond.

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Nonclinical Considerations for Ophthalmic Drug Development

Ophthalmic drug development comes with a unique set of challenges and complexities. To maximize your chance of success, it is best to rely on a drug development partner with regulatory knowledge, scientific and technical expertise, and a thorough understanding of the market in this growing therapeutic area.

In our latest podcast episode, learn about the key considerations for developing your ocular safety assessment program, including selecting the right animal model.

The Altascientist Consultant Series Podcast

Altasciences’ clients benefit from working with a single CRO/CDMO partner, from prototype formulation through preclinical testing, to early phase clinical trials, and manufacturing. This could mean up to 40% in both time and cost savings.

Have questions? Speak with one of our experts.

You might also be interested in:

Happy Holidays From Altasciences!

A song just for you!

Buddy the Elf once said, “The best way to spread holiday cheer, is singing loud for all to hear.” We couldn’t agree more.

This Holiday Season, we continue to be grateful and humbled by your partnership. Getting life-saving drugs to the people who need them, faster, is nothing short of amazing. Each new idea, discovery, trial, or success story from you, no matter how big or small, makes an impact—it’s another step forward for our global community. We can’t wait to see what we accomplish together in 2023.

To reflect on all we’ve given to each other, and to spread the joy, our Altascientists have prepared a special holiday song for you.

 

December 2022

Top 15 Scientific Resources of 2022

With the year coming to an end, we rounded-up some of our most insightful scientific resources from 2022. Check out what you missed, revisit the expertise we shared, and discover how Altasciences accelerates your drug development programs.

Preclinical Resources
  1. eBook: Nonclinical Safety Testing Guide for a Successful Regulatory Submission
    Use this guide to navigate your critical preclinical drug development program. Read or listen.
  2. Webinar: Case Studies — Adversity Level Determination in Nonclinical Toxicity Studies
    Get first-hand expert insight on common practices and guidances applied by CROs to characterize adversity. Watch now.
  3. Webinar: How Do I Select the Right Species for My Toxicology Program?
    Find out how your compound’s metabolism profile impacts species justification and IND-enabling program design. Watch now.
Clinical Resources
  1. The Altascientist: Issue 24 — Shortening Drug Development Timelines With Asian Ethnobridging Trials
    Uncover the ways in which ethnobridging can help minimize development time lags for drugs destined for Asian populations. Read or listen.
  2. Webinar: Inside the Pharmacodynamic Toolbox
    Learn how strategic design and targeted use of pharmacodynamic measures can greatly assist in evaluating the safety and potential efficacy of a new drug entity in the early stages of clinical development. Watch now.
  3. Webinar: The Many Advantages of Conducting Early Phase Clinical Trials in North America
    Discover the wide range of benefits of conducting clinical trials in North America, including access to diverse groups of participants and opportunities to accelerate your program. Watch now.
Manufacturing and Analytical Services
  1. The Altascientist: Issue 22 — Nanomilling for Better Solubility and Improved Bioavailability
    Dive into how patent extensions or 505(b)(2) new patents for poorly water soluble drugs currently on the market become possible with nanomilling. Read or listen.
  2. The Altascientist: Issue 28 — Applications of Liquid-Filled, Hard-Shell Capsules in Drug Development
    Explore the numerous applications of LFHCs as well as their formulation process development, the role of excipients, and their specific benefits during early phase clinical development. Read or listen.
  3. Podcast: Key Considerations as You Take Your Molecule From Formulation, to Development, to Commercialization
    Listen as our experts explain the benefits of partnering with an integrated CRO/CDMO that has the drug development and manufacturing expertise to move your product quickly from each development phase to the next, seamlessly. Listen now.
Bioanalytical Resources
  1. eBook: Key Biomarkers of Immunomodulation: Complement Factors and Cytokines
    Examine how personalized treatments for cancers and genetic diseases have pushed research and development for these conditions into biologics, vaccines, and small molecules that may have unintended consequences due to their immunomodulatory effects. Read or listen.
  2. eBook: Bioanalytical Developments for the Analysis of Antisense Oligonucleotides
    Discover how, with the ability to target the source of a disease's pathogenesis, antisense oligonucleotides demonstrate a promising modality for intractable diseases and hereditary disorders. Read or listen.
  3. Webinar: Development of a Cell-based Assay for Dual Purposes
    Learn how developing cell-based assays to identify biological activity and determine the presence of anti-drug antibodies can result in time and cost savings. Listen now.
Research Support Resources
  1. The Altascientist: Issue 26 — CDISC Data Standards
    See how you can get to sound, swift go/no-go decisions, with data that is of high quality and easy to interpret. Read or listen.
  2. Webinar: The Path Forward, Altasciences’ Approach to Project Management
    Watch to learn how Altasciences' project and program managers work with key internal and external stakeholders to lower program costs and reduce timelines by up to 40%. Watch now.
  3. Q&A: Setting Up Your Clinical Research for Success
    Set the foundation for the success of your clinical trial by partnering with a CRO that offers integrated and comprehensive research support services, such as protocol development and reporting. Read the Q&A or watch the full interview.

BONUS: Learn what over 143 pharmaceutical executives told us about the most important factors they look for when selecting a CRO partner. Read more.

Want to see more?


Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single study or multiple programs, to offer an integrated/synchronized approach to CRO and CDMO services from lead candidate selection to clinical proof of concept, and beyond.

Ophthalmic End-to-End Drug Development Solutions

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