Webinar

Get the most of Altasciences’ preclinical NHP expertise by attending two sessions, covering six distinct topics: 
1. feasibility analysis of two locations for radio telemetry device implantation 
2. spermatozoa evaluation in normal cynomolgus macaque
3. juvenile cynomolgus macaque infusion procedures 
4. cytokine data vs. in-life parameters in NHP
5. major immune cell populations in peripheral blood of naïve cynomolgus macaque 
6. assessment of receptor occupancy via flow cytometry

Central Nervous System (CNS) drug evaluation requires the assessment of specific safety endpoints, such as the drug’s potential to cause impairing effects on driving, the likelihood that it may be abused or misused, or the risk of causing withdrawal symptoms if abruptly discontinued. Evaluation of CNS effects in  Phase I studies can be very helpful in determining if dedicated driving simulator, abuse potential, and dependence studies are needed.

How hybridization ELISA can be an effective approach to quantify antisense oligonucleotides in circulation and in their targeted tissue.

• The advantages and limitations of hybridization ELISA
• The different types of hybridization ELISAs and how to choose the right format 
• The possible platforms to use for hybridization ELISA
• The common bioanalytical issues encountered and mitigation plans
• The most common challenges encountered with different matrices and tissues

A discussion on how bioanalytical data is used in early phase clinical trials to advance drug development.