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Blood sampling volume, frequency, and rate of collection could have scientific and animal welfare impact as well as challenge data validity and interpretation. General guidelines for blood collection volumes in laboratory animals are not species-specific.

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Hydromorphone Prodrug Associated With Fewer Abuse-Related Effects Compared With Hydromorphone May 28, 2019 Gary Rothbard https://www.clinicalpainadvisor.com/home/topics/opioid-addiction/hydrom…