Ligand Binding Assays
Our ligand binding group supports immunogenicity testing, PD, PK, BE, and biosimilar studies for both preclinical and clinical stages of drug development.
We have nearly a decade of experience with small and large molecules, such as oligonucleotides , small peptides, chemical elements, proteins, bi-specific antibodies, monoclonal antibodies, and antibody-drug conjugates. Our scientists will propose the most suitable equipment for your needs depending on the level of sensitivity, the complexity of your drug, or the need to multiplex or have a high-throughput sample analysis for your study.
Our ligand binding assay types:
- Immunogenicity assays:
- ADA: screening, confirmatory and titration
- nAb by non-cell-based and cell-based assays
- Quantification methods using various platforms
- Hybridization ELISA/ECLIA of various types (ligation, dual hybridization)
- Functional cell-based assays
- Biomarkers
- Cell lineage and functional immunophenotyping by flow cytometry
- PCR analysis (Droplet digital PCR, Quantitative PCR)
- Cytokine/Chemokine Analysis
- Electrochemiluminescence (ECL)
Our ligand binding equipment includes:
- Mesoscale S600 Electrochemiluminescence Sector Imager
- BioTek Synergy H4 Multimode Plate Reader using Absorbance, Fluorescence, or Luminescence
- Luminex 200 System
- Simoa HD-1 Analyzer
- BioTek EL406 Microplate Washer/Dispenser
- BD Biosciences FACSCantoTM II Cytometer
- SpeedVac for tissue extraction
- Percellys® Evolution Homogenizer